diff --git a/src/epomakercontroller/cli.py b/src/epomakercontroller/cli.py
index e8ed064..f5e5f1e 100644
--- a/src/epomakercontroller/cli.py
+++ b/src/epomakercontroller/cli.py
@@ -34,8 +34,17 @@ def wrapper(*args, **kwargs):
 
 @click.group()
 @click.version_option(retrieve_app_version(), prog_name="EpomakerController")
-def cli() -> None:
+@click.option(
+    "--interface",
+    type=int,
+    default=None,
+    help="HID interface to open, overriding INTERFACE in config.json. "
+         "Try another value if the keyboard misbehaves while a command runs.",
+)
+def cli(interface: int | None) -> None:
     """A simple CLI for the EpomakerController."""
+    if interface is not None:
+        CONFIG_MAIN.data["INTERFACE"] = interface
 
 
 @cli.command()
diff --git a/src/epomakercontroller/configs/default.json b/src/epomakercontroller/configs/default.json
index e7f783d..7c1091a 100644
--- a/src/epomakercontroller/configs/default.json
+++ b/src/epomakercontroller/configs/default.json
@@ -10,6 +10,7 @@
         16406
     ],
     "USE_WIRELESS": false,
+    "INTERFACE": 1,
     "DEVICE_DESCRIPTION_REGEX": "ROYUAN .* System Control",
     "CONF_LAYOUT_PATH": "EpomakerRT100-UK-ISO.json",
     "CONF_KEYMAP_PATH": "EpomakerRT100.json"
diff --git a/src/epomakercontroller/epomakercontroller.py b/src/epomakercontroller/epomakercontroller.py
index de08f8d..53109cc 100644
--- a/src/epomakercontroller/epomakercontroller.py
+++ b/src/epomakercontroller/epomakercontroller.py
@@ -58,6 +58,10 @@ def __init__(self, config_main: Config) -> None:
 
         self.vendor_id = config_main["VENDOR_ID"]
         self.use_wireless = config_main["USE_WIRELESS"]
+        # Which HID interface to open. None falls back to opening by
+        # vendor/product id, which takes whichever the backend enumerates
+        # first -- on Windows that is the only option available.
+        self.interface: Optional[int] = config_main["INTERFACE"]
 
         self.product_ids: list[int] = (
             config_main["PRODUCT_IDS_WIRED"]
@@ -170,6 +174,26 @@ def _find_product_id(self) -> Optional[int]:
 
         return None
 
+    def _find_interface_path(self, product_id: int) -> Optional[bytes]:
+        """Path of the configured HID interface, or None to open by id.
+
+        Returns None when no interface is configured, or when the backend does
+        not report interface numbers -- notably on Windows, where hidapi
+        reports -1 and opening by vendor/product id is the only option.
+        """
+        if self.config.interface is None:
+            return None
+
+        for entry in hid.enumerate(self.config.vendor_id, product_id):
+            if entry.get("interface_number") == self.config.interface:
+                return entry["path"]
+
+        Logger.log_warning(
+            f"Interface {self.config.interface} not found on device "
+            f"{self.config.vendor_id:04x}:{product_id:04x}, opening by id instead"
+        )
+        return None
+
     def _open_device(self, product_id: int) -> None:
         """Opens the USB HID device.
 
@@ -177,7 +201,11 @@ def _open_device(self, product_id: int) -> None:
             product_id (int): The product ID.
         """
         try:
-            self.device.open(self.config.vendor_id, product_id)
+            path = self._find_interface_path(product_id)
+            if path is not None:
+                self.device.open_path(path)
+            else:
+                self.device.open(self.config.vendor_id, product_id)
         except IOError as e:
             Logger.log_error(
                 f"Failed to open device: {e}\n"
diff --git a/tests/data/config/config.json b/tests/data/config/config.json
index f709122..312d654 100644
--- a/tests/data/config/config.json
+++ b/tests/data/config/config.json
@@ -10,6 +10,7 @@
         16406
     ],
     "USE_WIRELESS": false,
+    "INTERFACE": 1,
     "DEVICE_DESCRIPTION_REGEX": "ROYUAN .* System Control",
     "CONF_LAYOUT_PATH": "EpomakerRT100-UK-ISO.json",
     "CONF_KEYMAP_PATH": "EpomakerRT100.json"