In fact, Genesis Plus GX can actually run Sega Pico games (this is due to Sega Pico having same hardware as Genesis), but they will be unplayable, since Magic Pen is not supported. However, due to Sega Pico having the same hardware as Sega Genesis, it is easy to add support for it, simply learn how to add Sega Pico support to an emulator and add it as a console mode.
The only difference here is the audio processor Yamaha YM2612 FM synthesis-based sound chip is absent, and the Texas Instruments SN76489 PSG is accompanied with NEC ųPD7759 ADPCM chip, which can produce extra sound effects.
In fact, Genesis Plus GX can actually run Sega Pico games (this is due to Sega Pico having same hardware as Genesis), but they will be unplayable, since Magic Pen is not supported. However, due to Sega Pico having the same hardware as Sega Genesis, it is easy to add support for it, simply learn how to add Sega Pico support to an emulator and add it as a console mode.
The only difference here is the audio processor Yamaha YM2612 FM synthesis-based sound chip is absent, and the Texas Instruments SN76489 PSG is accompanied with NEC ųPD7759 ADPCM chip, which can produce extra sound effects.