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2 followers · 6 following
  • Albert Einstein College of Medicine
  • Bronx, NY
  • X @JacobRoth13

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rothjs-PhD/README.md
  • 👋 Hi, I’m @rothjs-PhD
  • I love exploring the world around me and am captivated by asking “why.” I am not satisfied by simple answers; I love challenges and approach each new problem as a puzzle waiting to be solved.
  • Throughout my PhD, I studied Protein Arginine Methyltransferase 5 (PRMT5), a cell-essential protein that is often over-expressed in cancer and thus a target of multiple clinical-stage chemotherapies. I discovered that PRMT5 is required for histone protein regulation, potentially by mediating a direct feedback loop via methylation of non-nucleosomal histone H4. This discovery redefines PRMT5 as a central regulator of histone homeostasis and provides a mechanistic basis for understanding its essential role in proliferating cells. By directly linking arginine methylation to histone production, I offer a new framework for understanding how PRMT5 inhibition induces genome instability and explain why PRMT5 is critical for cancer: rapidly dividing cells require over-expression of PRMT5 to drive production of histones. [https://www.biorxiv.org/content/10.1101/2025.07.03.663002v1]
  • Reach me at jacob.roth@einsteinmed.edu - lets chat!

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  1. DataManagement DataManagement Public

    Some of my acquired systems for improving data management and record-keeping.

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