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second-order-difference

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LovelaceSquare / birfi-ls-smoothing

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BIRFI estimates the IRF via least squares and smoothing penalty from the fluorescence decay itself.

matlab convolution microscopy spectroscopy chemometrics tikhonov-regularization blind-deconvolution hankel-matrix inverse-problem trfs instrument-response-function penalized-least-squares second-order-difference birfi irf-estimation time-resolved-fluorescence fluorescence-decay regularized-inversion signal-recovery smoothing-penalty
  • Updated Aug 7, 2026
  • MATLAB

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